European Lion Facts and Figures

European Lion Facts and Figures Panthera leo, the cutting edge lion, incorporated a befuddling exhibit of subspecies in early authentic occasions. At any rate three of these-Panthera leo europaea, Panthera leo tartarica and Panthera leo fossilis-are alluded to all things considered as the European Lion; these enormous felines occupied an expansive area of western, focal and eastern Europe, extending from the Iberian landmass to as far east as Greece and the Caucasus. The European Lion most likely slid from a similar regular predecessor as the Asiatic Lion, Panthera leo persica, the still-surviving leftovers of which can in any case be found in current India. Social References Tantalizingly, the European Lion is referenced various occasions in old style writing; the Persian ruler Xerxes apparently experienced a few examples when he attacked Macedonia in the fifth century B.C.E, and this huge feline was in all likelihood utilized by the Romans in gladiatorial battle or to discard appalling Christians in the first and second hundreds of years A.D. Like other Panthera leo subspecies, the European Lion was pursued to annihilation by people, either for sport or to secure towns and farmland, and vanished off the substance of the earth around 1,000 years prior. The European Lion ought not be mistaken for the Cave Lion, Panthera leo spelaea, which made due in Europe and Asia up to the cusp of the last Ice Age. Realities Chronicled Epoch Late Pleistocene-Modern (one million-1,000 years prior) Size and Weight Up to four feet high at the shoulder and 400 pounds Recognizing Characteristics Huge size; absence of manes in females

Merck case report Essay Example

Merck case report Essay Dismissing Mr.. Mercers theory, the program proposes to not Invest In sedate rights because of a general loss of $260,000. Stage One: The KILL-798 item has been under trying stages for a half year. In light of Kappa Labs venture group examine there Is a 60% possibility of Phase One effective finish. If Merck somehow managed to purchase the item rights, the expense Incurred to finish this would be $5 million. The product states there Is an opportunity of Phase One coming up short bringing about lost $35 million. In the event that the first round demonstrates effective, at that point Merck faces the choice of advancing to Phase Two. Stage Two: If Merck chooses to progress into Phase Two there presents a large number of chances. The main choice includes treating only heftiness at 10% probability. A 10% possibility additionally exists of the medication treating just elevated cholesterol. There additionally is a chance of the medication adequately tending to the two conditions at 30%. The possibility of the medication not treating any of the diseases is half. The expense of finishing Phase Two is $40 million. For each condition that is tended to, the choice remains whether to search out FDA endorsement. The program recommends if Phase Two is effective, the numerous has two plausible choices, to deliver a medication for Just stoutness or achieve a medication that battles both heftiness and cholesterol. The more pragmatic choice for the organization is to deliver a medication that tends to just weight since there is a higher by and large benefit when contrasted with creating a medication that objectives the two illnesses. The medication that objectives just stoutness has a general advantage of $197. Million, while the medication that objectives the two has a general advantage of $160. 5 million. FDA Approval: The choice tree encourages Merck to search out FDA assent. For the item that treats just heftiness, there is a 75% possibility of getting FDA acknowledgment. This would cost Merck $50 million to proceed with this procedure. In the wake of looking for endorsement, the organization Is co nfronted with the choice whether to showcase the medication. In the event that the medication Is affirmed and showcased, an addition of $430 million will be accomplished. We will compose a custom article test on Merck case report explicitly for you for just $16.38 $13.9/page Request now We will compose a custom exposition test on Merck case report explicitly for you FOR ONLY $16.38 $13.9/page Recruit Writer We will compose a custom paper test on Merck case report explicitly for you FOR ONLY $16.38 $13.9/page Recruit Writer The following alternative Is to choose If we should proceed to FDA endorsement for the medication that treats just cholesterol. Choice Tree Analysis encourages Merck to not proceed with this procedure despite the fact that a 75% possibility exists of achieving endorsement. The expense of looking for acknowledgment Is $50 million. The third alternative Is to settle on looking for FDA acknowledgment for a medication that treats tooth illnesses. Concurring too nitty gritty examination, creating this medication Is additionally a suitable alternative, in spite of the fact that the advantage would be not exactly delivering for just heftiness. Affectability Analysis: The main examination directed was on accomplishing achievement in Phase I Nils apneas Is amazingly delicate up until purportedly up until tens rate, the normal worth is negative. Any likelihood more noteworthy than 60% outcomes in a positive anticipated worth. On the off chance that the likelihood increments by 1%, the program choice will change to propose the organization to push ahead (it would be ideal if you allude to Decision Tree 2). For the second affectability examination, we set the choice with the most elevated chance as the consistent, which is the choice to deliver neither medication. This alternative additionally ends up being exceptionally delicate at the half likelihood mark. In the event that the rate were to be more prominent than half, at that point it would not be ideal to push ahead. The last examination included the likelihood of the two medications accepting FDA endorsement. Like the past two investigation, a worth higher than 60% will bring about a normal worth that is certain. This outcomes in the medications getting acknowledgment. Agreement: According to Decision Tree footwear, the ideal suggestion is to not buy sedate rights. This outcomes in neither benefits or misfortunes, and the ideal circumstance for the Merck association. In the event that the firm were to initially employ a counseling firm to explore the likelihood of accomplishment in stage one and the specialists demonstrate that achievement is reasonable, the estimation of giving this data brings about a general advantage of $57. 9 million. This gives a $55. 3 million contrast from not employing an expert of $2. 635. Hence, Merck could procure an expert up until the expense of this distinction (it would be ideal if you allude to Decision Tree 3).

American culture at its finest Thanksgiving

American culture at its finest Thanksgiving The fourth Thursday of November and the few days before and after are typically the biggest travel days in the U.S. Why? Because that day (today!) is Thanksgiving day, which is a BIG DEAL in the U.S. Considering the size of our international audience, I thought I might take a few minutes to explain why. Thanksgiving is when Americans gather together with their families to take part in a few time-honored traditions: huge, home cooked meals centered around a turkey, football (the American kind, not actually played with your feet), and preparation for the holiday season. I just watched the Macys Thanksgiving Day Parade, another staple of the holiday. Apparently (according to Wikipedia, anyway) the parade began back in the 20s because a large number of Macys employees were new immigrants who were eager to embrace American traditions. (You learn something new every day.) Macys is a huge department store, the main branch of which is located on 34th street in New York City. (Hence the movie title.) In fact, I just passed Macys on Tuesday night- the bus I take drops me off at Penn Station, right across the street from the famous store. So back in the 20s, a bunch of Macys employees put together a big parade with balloons, floats, and animals from the Central Park Petting Zoo, and a great American tradition was born. Ever since its first incarnation, the parade ends with the entrance of Santa Claus- the official ringing in of the holiday season. (In fact, before Thanksgiving was officially encoded as the 4th Thursday in November, presidents during lean tim es attempted to move the holiday earlier in the year to increase the length of the shopping season. I really need to read less Wikipedia.) At my house, Thanksgiving morning is pretty lax. While delicious cooking happens in the kitchen, the TV in the living room is left on channel 4 (NBC) which broadcasts the parade every year. My mom and/or sister and I take breaks from preparing some food to bring to my grandparents house to catch snippets of the parade on TV. We never sit down and watch the whole thing, but everyone makes sure to catch the very end, when Santa makes his appearance. But before the climactic end, the parade features marching bands from across the country, floats with famous performers singing and dancing to holiday tunes, and huge balloons of characters from all arenas of pop culture: books (the Cat in the Hat, Clifford the Big Red Dog), TV shows (Kermit the frog), movies (Buzz Lightyear), toys (Mr. Potato Head), and even commercials (the Energizer Bunny, the MMs characters.) And a fun fact: apparently, engineering students from Stevens Institute of Technology in Hoboken, NJ volunteer at the parade by inflating the balloons and using their physics knowledge to train the handlers in keeping the balloons under control. I almost went there, and I never knew that! After my family enjoys the parade, we head to my grandparents house with as many of my moms sibilings as can make it (my moms sisters both live nearby, but her 2 brothers live out of state and only make it back to Jersey every couple of years for important family events) for a traditional dinner: turkey, mashed potatoes, cranberry sauce, pumpkin pie, and all sorts of other autumn foods. Not only that, but my grandmother actually works in a bakery, so the pies and cookies are always top-notch (and in oversupply, normally). My extended family is huge, so we almost never have a formal sit-down dinner like you see on TV. All sorts of food is set out and everyone grabs what they want and finds a place around the house to sit down and enjoy. As for the football: the TV in the background is set to the football game, and after weve digested a bit, we head outside for a family match. A few years ago, when we had a larger crowd than usual thanks to my uncle and his family flying in from Utah, my mom actually borrowed pinnies from the basketball team she coaches so we could have proper teams. It can get pretty intense. This is my family playing football a few Thanksgivings ago. We pick teams after dinner, and the winners take pride in rubbing victory in the face of the losing team for an entire year. Im not kidding. Its a big deal. The story behind the first Thanksgiving goes as follows: the pilgrims who landed in Massachusetts had no idea what they were doing. They were totally unprepared for New England winters and certainly wouldnt have made it through the first few years without the help of the Native Americans in the area who taught them how to fish and hunt local game, which crops to plant, and generally how to survive on the terrain. To express their thanks, the pilgrims and the Native Americans held a big feast together to celebrate a successful harvest. But every story has two sides. If it seems a little bogus to you that one of the biggest, most culturally important holidays in the U.S. celebrates the help of an indigenous population which weve historically, to put it mildly, treated very poorly, youre not alone. The United American Indians of New England agree with you, and since 1970 theyve staged a protest on Thanksgiving Day (called the National Day of Mourning) in Plymouth, Massachusetts- the site of the original Thanksgiving to protest the myth of the First Thanksgiving (because we all know the story wasnt that simple, and the way we celebrate the holiday now almost certainly bears very little resemblance to the original) and the even bigger myth of cooperation between the natives and the settlers. I think thats a pretty comprehensive overview of the holiday. Enjoy your turkey, your protests, or your ordinary autumn day- whatever is in store for you.